Yazar "Erdogan, Mumin Alper" için listeleme
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Ameliorating Effect of Propofol on Cisplatin -Induced Liver and Kidney Damage in Rats
Ozkul, Ozlem; Ozkul, Bahattin; Erdogan, Mumin Alper; Erbas, Oytun (Asian Network Scientific Information-Ansinet, 2022)Background and Objective: Cisplatin is among the most frequently used in solid organ cancers. However, it can be dose-limiting, especially due to its side effects on the kidney and liver. This study aims to examine the ... -
Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model
Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Gunenc, Damla; Erbas, Oytun (HINDAWI LTD, 2017)The most severe side effect of prolonged MTX treatment is hepatotoxicity. The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model. Twenty-four male rats were ... -
Demonstration of the protective effect of propofol in rat model of cisplatin-induced neuropathy
Gonullu, Edip; Dagistan, Gozde; Erkin, Yuksel; Erdogan, Mumin Alper; Erbas, Oytun (Aepress Sro, 2023)Cisplatin is commonly used in the treatment of lung, genitourinary, and gastrointestinal cancers. Peripheral neuropathy is the most important side effect, leading to a decrease in the dose of cisplatin or its complete ... -
Dexpanthenol reduces fibrosis and aids repair following nerve laceration and neurorrhaphy
Karahan, Gokhan; Kaya, Huseyin; Eyceyurt, Recep Selcuk; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun (Spandidos Publ Ltd, 2021)The aim of the present study was to investigate the effect of dexpanthenol on nerve healing following neurorrhaphy in lacerated peripheral nerves. A total of 30 mature Sprague Dawley rats were used. Surgical sciatic nerve ... -
Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia
Erdogan, Mumin Alper; Kirazlar, Mehmet; Yigitturk, Gurkan; Erbas, Oytun (Springer/Plenum Publishers, 2021)Alzheimer's disease (AD) is by far the most common cause of cognitive impairment in older adults. Current treatments are entirely focused on the symptoms of AD. A complex etiology for AD has been proposed recently, in which ... -
Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia
Erdogan, Mumin Alper; Kirazlar, Mehmet; Yigitturk, Gurkan; Erbas, Oytun (Springer/Plenum Publishers, 2022)Alzheimer's disease (AD) is by far the most common cause of cognitive impairment in older adults. Current treatments are entirely focused on the symptoms of AD. A complex etiology for AD has been proposed recently, in which ... -
Effect of Lipid Emulsion on the Improvement of Renal Damage in Colist-in-Induced Nephrotoxicity
Senkal, Naci; Atasoy, Ozum; Caparali, Emine Bilge; Erdogan, Mumin Alper; Erbas, Oytun (Bentham Science Publ, 2021)Background: Colistin utilization has gradually increased worldwide with the rising of multidrug-resistant (MDR) gram-negative bacilli despite its nephrotoxicity. Lipid emulsion (LE) is widely used for the toxic overdose ... -
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions
Erdogan, Arife; Erdogan, Mumin Alper; Gurgul, Serkan; Erbas, Oytun (Springer/Plenum Publishers, 2023)Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available anticonvulsant medications, indicating the need for further research into ... -
The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats
Bora, Saylav; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Parlak, Ismet (HUMANA PRESS INC, 2018)The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO4 which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty ... -
Effects of prenatal testosterone exposure on the development of autism-like behaviours in offspring of Wistar rats
Erdogan, Mumin Alper; Bozkurt, Mehmet Fatih; Erbas, Oytun (Wiley, 2023)BackgroundA neurodevelopmental disease, autism spectrum disorder (ASD) occurs in males three times more commonly than girls. Higher prenatal testosterone exposure may result in autistic-like behaviour in boys, according ... -
Effects of the Calcium Channel Blocker Otilonium Bromide on Seizure Activity in Rats With Pentylenetetrazole-Induced Convulsions
Erdogan, Arife; Erdogan, Mumin Alper; Atasoy, Ozum; Erbas, Oytun (Springer/Plenum Publishers, 2021)Millions of people suffer from drug-resistant epilepsy. New therapeutic approaches for removing this life-affecting disease are required. The activation of T-type calcium channels (TTCC) is one of the epileptogenesis ... -
Effects of the Prenatal Administration of Tetanus Toxoid on the Sociability and Explorative Behaviors of Rat Offspring: A Preliminary Study
Sunnetci, Eda; Durankus, Ferit; Albayrak, Yakup; Erdogan, Mumin Alper; Atasoy, Ozum; Erbas, Oytun (Korean Coll Neuropsychopharmacology, 2021)Objective: Autism spectrum disorder (ASD) is a severely disabling psychiatric disease characterized by impairments in communication and social skills. Although efforts have been made to explore the etiology of ASD, its ... -
Erythropoietin shows gender dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide induced rat model of autism
Solmaz, Volkan; Erdogan, Mumin Alper; Alnak, Alper; Meral, Ayfer; Erbas, Oytun (Churchill Livingstone, 2020)We aimed to evaluate the effects of EPO in the lipopolysaccharide (LPS) induced rat model of autism in terms of social deficits, learning and memory impairments, as well as their neurochemical correlates. Sixteen female ... -
Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study
Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Solmaz, Volkan; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Taskiran, Dilek (WILEY, 2018)The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group ... -
Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions
Solmaz, Volkan; Tekatas, Aslan; Erdogan, Mumin Alper; Erbas, Oytun (Wiley, 2020)Previous studies have established anti-inflammatory, antioxidant, and neuroprotective effects of Exenatide in the central nervous system. Since these mechanisms are thought to have important roles in the pathophysiology ... -
An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Alper, Sibel; Erbas, Oytun (Hindawi Ltd, 2021)Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. ... -
Granulocyte colony-stimulating factor has a sex-dependent positive effect in the maternal immune activation-induced autism model
Durankus, Ferit; Albayrak, Yakup; Erdogan, Firat; Albayrak, Neslihan; Erdogan, Mumin Alper; Erbas, Oytun (Wiley, 2022)Objective The medical intervention for autism spectrum disorder (ASD) is restricted to ameliorating comorbid situations. Granulocyte colony-stimulating factor (G-CSF) is a growth factor that enhances the proliferation, ... -
The Healing Effect of Digoxin on Peripheral Nerve Damage and Its Relation to IL-17/IL-10
Gurkan, Gokhan; Erdogan, Mumin Alper; Karahan, Gokhan; Kaya, Huseyin; Yigitturk, Gurkan; Kizmazoglu, Ceren; Erbas, Oytun (Turkish Neurosurgical Soc, 2023)AIM: To demonstrate the curative effect of digoxin on peripheral nerve damage with its anti-inflammatory role on interleukin (IL)-17. MATERIAL and METHODS: The study was conducted with 30 male Sprague Dawley albino mature ... -
Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy
Erdogan, Mumin Alper; Yusuf, Dimas; Christy, Joanna; Solmaz, Volkan; Erdogan, Arife; Taskiran, Emin; Erbas, Oytun (BIOMED CENTRAL LTD, 2018)Background: Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), ... -
Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2? Burst in the Brain of PTZ-Treated Rats
Pazarlar, Burcu Azak; Egilmez, Cansu Bilister; Erdogan, Mumin Alper; Erbas, Oytun (Springer/Plenum Publishers, 2023)It is still an urgent need to find alternative and effective therapies to combat epileptic seizures. Tacrolimus as a potent immunosuppressant and calcineurin inhibitor is emerging as promising drug to suppress seizures. ...